Endocrine Abstracts

Thyroid hormones are evolutionarily conserved iodine-containing regulators of metabolism and development (reviewed by Mullur et al. (2014)). A key process in synthesis of the effectors thyroxine and tri-iodothyronine is the uptake of iodide from the bloodstream into thyroid follicular cells by the sodium-iodide symporter channel (NIS) encoded by the solute-carrier gene SLC5A5. Perturbation of NIS activity by environmental chemicals can lead to rapid and potent changes...

Thyroid hormones are important regulators of metabolism and development. Iodothyronine selenodeiodinases can both activate and inactivate thyroid hormones (Bianco et al. 2002) thus in vitro assays to quantify deiodinase inhibition are considered to be a valuable tool for studying effects on thyroid hormone metabolism by potential endocrine disruptors. The prohormone thyroxine (T4) is converted to 3, 5, 3’-triiodothyronine (T3) by outer-ring deiodination,...